PSC — Primary Sclerosing Cholangitis

Primary sclerosing cholangitis is a health condition that affects the bile ducts, which are responsible for transporting bile from the liver to the small intestine. Bile is a fluid involved in digestion, and when a person develops primary sclerosing cholangitis, they have inflammation that leads to scarring in the bile ducts.

Over time, scars in the bile ducts cause them to become hard and narrow, slowly leading to liver damage as the disease progresses. Disease progression is typically slow with primary sclerosing cholangitis, so people who have the condition may generally feel pretty well in the early stages. That being said, disease progression can vary between people.

What causes primary sclerosing cholangitis?

While the exact cause of primary sclerosing cholangitis is difficult to determine, it may be the result of an immune system reaction in people who have a genetic predisposition to it. For example, a toxin or infection can trigger an immune system response that leads to primary sclerosing cholangitis in some people. A significant proportion of people with primary sclerosing cholangitis also have ulcerative colitis or Crohn’s disease, which are inflammatory bowel conditions.

Is primary sclerosing cholangitis serious?

Primary sclerosing cholangitis can lead to serious complications over time. For instance, inflammation and scarring from the condition can lead to liver cirrhosis, death of liver cells, and eventually liver failure. Additional complications include repeated bile duct infections as well as high blood pressure in an important blood vessel called the portal vein. The latter can cause veins to become swollen and weak, ultimately leading to life-threatening bleeding. Other complications include thinning bones and increased risk of colon cancer and bile duct cancer.

How is primary sclerosing cholangitis treated?

If you have primary sclerosing cholangitis, your doctor will monitor the functioning of your liver and provide care to manage your symptoms. While no medications have been shown to slow or reverse liver damage with primary sclerosing cholangitis, there are medications available to treat symptoms of the disease. For instance, certain medications may relieve itching, and antibiotics can treat infections that occur when bile is backed up in narrow or blocked ducts. A doctor may also place a stent or complete a balloon dilation to treat blocked bile ducts. If you experience liver failure with primary sclerosing cholangitis, the only cure is to receive a liver transplant from a healthy donor.

Common Symptoms

  • “I felt tired all the time, and I experienced itching all over my body.”
  • “As my condition got worse, I started to have pain in the upper right area of my abdomen, as well as frequent fevers and night sweats.”
  • “I started to lose weight, and I had yellowing in my skin and eyes.”


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What Our Patients Are Saying

I’ve been a patient of Dr. Weber for almost a decade. My husband for more than & it was he who recommended Dr. Weber. He’s knowledgeable & well experienced in his field. Plus he’s an all around kind & nice guy. And you’d like how the office & tech staff are trained to run the operation of this practice. Efficient, patient and helpful! I’d feel very comfortable recommending this practice.

Vicki M.

I had a great time. Everyone was very friendly and professional. One nurse said I had nice eyes, which really helped my self esteem. Dr. Willie was fantastic. His concern about having magenta ink for the printer really shows what a caring man he is. The pictures turned out great. I framed them and hung them up on my wall at home. But, seriously the experience was pleasant. Thank you to everyone involved.

Terry M.

Lord knows having a colonoscopy is zero fun. The prep nearly did me in. But after arriving at suite 270 every single person was pleasant and efficient. The attention to cleanliness in the office is very apparent and appreciated. Every employee introduced themselves by name, apologized for an IV that took two tries and made sure I was as comfortable as can be before I was ready to leave. However, I’m going to enjoy every minute of the five years before I need to return!

Marie C.

I have been here several times and have always been treated great. The receptionist are so kind and the nurses are wonderful so is the anesthesia person are so kind and answers any concerns you might have. My Dr Bologna is awesome. This is the place to go if you need endoscopy or colonoscopy. Thank all the staff for being so kind

Debbie A.

Our Doctors

We’re proud of our team here at Digestive Health Institute. Our health care providers include some of the very best colorectal surgeons, gastroenterologists and physician assistants. To learn more about our qualified team of specialists, please visit our providers page.

Anezi E. Bakken MD, MS

Sante D. Bologna MD, FACP

M. Emin Donat MD, FRCPC

Freeha Khan MD

Partha S. Nandi

Leonard G. Quallich III MD

Jack Tocco DO

John R. Weber MD

Richard T. Wille MD

Tusar Desai MD

Aalia Saeed, MD


What happens during my first visit?
If you are a new patient, you can expect to have a complete physical exam. You will also be asked detailed questions about your current problems and your past medical history, your current medications, allergies, your family history and other pertinent medical information. If you are taking medications, please bring a completed medical history form with you to your appointment. Once the physician has reviewed your medical information and completed the physical examination, a plan of care will be developed. You may need to be seen again in the office, be referred back to your family physician for follow-up care, or require additional testing. If additional tests are needed, we will assist you in scheduling these tests.
What if I need to schedule an endoscopic procedure?

An endoscopic procedure allows the physician to visualize a part of your gastrointestinal tract with a special instrument called an endoscope. If your family physician has ordered testing, you will be contacted by telephone by one of our staff members. If a physician orders testing and you are in the office, the procedure can generally be scheduled during the course of your visit. You will be given a date, time, and location for the test, as well as written instructions telling you how to prepare for the test. If you have any questions about the procedure, please feel free to ask one of our staff members or the physician.

How do I get test results?

We ask that you wait 10 to 14 days before contacting us for results. Often results come from several different sources. This information needs to be compiled and reviewed by your physician before you can be appropriately advised. 

What insurances do you accept?

We accept payment from most insurance companies including Medicare, Blue Cross/Blue Shield, Blue Care Network, Physicians Health Plan, Cofinity, Sparrow Professional Health Network, Medicaid, McLaren, Health Plus, and several others. Accepted insurances are subject to change at any time without notice.

If your insurance requires an authorization from your primary care physician, you may be asked to assist us in obtaining this authorization.

All patients are responsible for all copays and deductibles at the time of service.

If you have any questions regarding your benefits or insurance coverage, please contact our Billing Department at 248-844-9710.

What if I need to contact the doctor?

To contact your doctor during business hours please call our main number 248-844-9710. If you have an urgent need to speak with the doctor after hours, you will be rerouted to our after hours answering service, and your doctor will be paged. In the case of a medical emergency please proceed directly to the nearest hospital emergency room.

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